A postdoctoral research fellowship is available in our laboratory in the Cardiovascular Research Institute at the University of California San Francisco, Mission Bay Campus. Interested candidates should send their CV along with 3 letters of recommendation to Kamran Atabai, M.D. at Kamran.Atabai@ucsf.edu.
Our laboratory is interested in the cellular mechanisms by which fatty acids are absorbed in the gut, processed within enterocytes for storage as cytoplasmic lipid droplets and/or exported as chylomicrons and distributed to peripheral tissues for utilization or storage. In addition to better understanding the mechanisms that regulate enterocyte lipid storage, we are particularly focused on understanding the mechanism by which cellular uptake of fatty acids by peripheral organs (such as the white adipose tissue, liver, and skeletal muscle) induces insulin resistance. We have been studying the role of integrin receptors and in particular the extracellular matrix model and integrin ligand Mfge8 in this process. We use a combination of in vitro and in vivo techniques to dissect out the mechanisms by which these processes are regulated primarily using mouse models of metabolism. We also have access to a large cohort of human adipose tissue samples from obese patients to correlate our discoveries in model systems with human disease. The fellow can expect to actively participate in experimental design, the writing of manuscripts and grant applications, and participation in both local, national, international scientific meetings. At the end of the fellowship, the trainee should be in an optimal position to embark on an independent scientific career.
The position requires a highly organized and motivated individual that holds an M.D. or a Ph.D. in a relevant field and is ultimately interested in successfully competing for an independent academic position. The applicant should be no more than 2-3 years from the time she/he finished their M.D. or Ph.D. training. Experience in cellular and molecular biology is optimal. The candidate should expect that working with mice will be a big part of the research program.
Additional Salary Information: The salaries based on the NIH pay scale and PGY level, it is possible to negotiate a supplement based on lab funding